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Rischio cardiovascolare e malattia di Parkinson

Cereda E, Cassani E, Barichella M, Caccialanza R, Pezzoli G. Anthropometric indices of fat distribution and cardiometabolic risk in Parkinson's disease. Nutr Metab Cardiovasc Dis. 2011 Sep 7. [Epub ahead of print]

Abstract

BACKGROUND & AIMS: To investigate the association between anthropometric indices of body fat distribution and cardiometabolic risk factors in a population of Parkinson's disease (PD) patients. METHODS & RESULTS: One hundred and fifty-seven PD patients (57.3% males) were studied measuring: waist circumference (WC), waist-hip ratio (WHR), waist-to-height ratio (WtHR), body fat percentage (BF%) by impedance, fasting glucose, serum lipids. Information was collected also on diabetes, hypertension and metabolic syndrome (MetS). Increased cardiometabolic risk was defined by ≥2 MetS component traits other than abdominal adiposity. In the whole population, prevalence of overweight and obesity were 35.0% and 19.2%, respectively. However, prevalence of MetS and elevated cardiometabolic risk were 14.6% and 18.5%, respectively. Prevalence was similar between genders, with one exception: adverse fat distribution according to WC and WHR was more common in females (P < 0.001). Using a multivariable model (adjustments: age, smoking status and disease duration), indices were highly correlated with BF% in both genders. WC and WtHR were associated with the number of MetS criteria and elevated risk. The only cardiometabolic parameters associated with anthropometric indices were HDL in men and triglycerides in women. After adjusting also for BMI all the associations found with anthropometric indices disappeared. CONCLUSIONS: Despite their correlation with BF%, anthropometric indices of body fat distribution appear to poorly account for the reduced cardiometabolic risk of the PD patient. This finding suggests a low metabolic activity within the adipose tissue. The implications of fat distribution on the cardiometabolic risk of PD patients clearly deserves further investigation.

INDICATORI ANTROPOMETRICI DI DISTRIBUZIONE DELLA MASSA GRASSA E RISCHIO CARDIOMETABOLICO NELLA MALATTIA DI PARKINSON (PD)

Sono stati studiati 157 pazienti (57.3% ♂) affetti da PD. Per tutti i soggetti sono state raccolte le misure antropometriche (con particolare attenzione agli indicatori della distribuzione del grasso corporeo, come la circonferenza vita (WC), il rapporto vita/fianchi (WHR) e il rapporto vita/altezza (WtHR)), è stata calcolata la percentuale di grasso tramite bioimpedenziometria e sono stati individuati gli indicatori biochimici di rischio cardiometabolico (glicemia, colesterolemia HDL, trigliceride mia). Inoltre, è stata indagata l’eventuale presenza di malattie metaboliche, come il diabete mellito e l’ipertensione arteriosa. Si è osservato che gli indicatori della distribuzione del grasso corporeo (WC; WHR; WtHR) correlano con la percentuale di grasso corporeo, ma hanno scarsa correlazione con gli indicatori di rischio cardiometabolico. Questo risultato depone per una bassa attività metabolica del tessuto adiposo dei pazienti PD ed è meritevole di ukteriori approfondimenti.